Polyhexamethylene biguanide, hydrochloride;
PHMB hydrochloride;
CAS Number: 32289-58-0; 27083-27-8;

Katyonik geniş spektrumlu bir antimikrobiyal ajan olan PHMB hidroklorür, hücre zarı aktivitesini inhibe ederek bakterisidal amaca ulaşır.

Hücre zarı aktif bir antimikrobiyal ajan olarak PHMB, bakteriyel aktiviteyi mantarlardan daha iyi inhibe eder ve antimikrobiyal mekanizması kabaca aşağıdaki gibidir:
PHMB, genellikle negatif yüklü olan çeşitli bakteri türleri tarafından kolayca adsorbe edilen, böylece bakterilerin bölünme işlevini engelleyen ve bakterilerin üreme yeteneklerini kaybetmelerine neden olan polimerize katyonik bir bileşiktir.

	Solution	Solid
Appearance	Colorless clear to slightly pale yellow liquid	White to slight yellow hygroscopic powder
Odor	Characteristic	Characteristic
Turbidity [NTU]	Max. 10	—
Solid component [％]	19.0 to 21.0	Min. 95.0
Density at 20℃ [g/ml]	1.039 to 1.050	—
pH-Value at 25℃	4 to 6	4 to 7
Absorbance value (1%, 237nm)	Min. 400	Min. 400
Absorbance ratio (237nm / 222nm)	1.2 to 1.6	1.2 to 1.6

The following is the original English text.
Aşağıda orijinal İngilizce metin verilmiştir.

Polyhexamethylene biguanide, hydrochloride;
PHMB hydrochloride

CAS Number: 32289-58-0; 27083-27-8;
Formula:
1. CAS 32289-58-0: (C8H17N5·ClH)n; Poly(iminoimidocarbonyliminoimidocarbonyliminohexamethylene), hydrochloride;

2. CAS 27083-27-8: (C10H18N8·C6H16N2)x·xClH; Guanidine, N,N”’-1,6-hexanediylbis[N’-cyano-, polymer with1,6-hexanediamine, hydrochloride;

3. CAS: 91403-50-8; EC: 618-745-0;
IUPAC names: Poly(hexamethylenbiguanid)-hydrochlorid

PHMB hydrochloride, a cationic broad-spectrum antimicrobial agent, achieves bactericidal purpose by inhibiting cell membrane activity.

As a cell membrane active antimicrobial agent, PHMB inhibits bacterial activity better than that of fungi, and its antimicrobial mechanism is roughly as follows:
PHMB is a polymerized cationic compound, which is easily adsorbed by various types of bacteria that are usually negatively charged, thus inhibiting the division function of the bacteria and making the bacteria lose the ability to reproduce.

Features:
1. HPMB has the ability to inhibit Gram-positive bacteria, Gram-negative bacteria, fungi (many kinds of ringworm and mold) and yeast.
2. PHMB has rapid inhibitory effect on E. coli, Staphylococcus aureus and Candida albicans.
3. PHMB: LD50＞5000mg/kg, HPMB is skin friendly, human and environment friendly.

Technical Data:

	20% Solution	Solid
Appearance	Colorless clear to slightly pale yellow liquid	White to slight yellow hygroscopic powder
Odor	Characteristic	Characteristic
Turbidity [NTU]	Max. 10	—
Solid component [％]	19.0 to 21.0	Min. 95.0
Density at 20℃ [g/ml]	1.039 to 1.050	—
pH-Value at 25℃	4 to 6	4 to 7
Absorbance value (1%, 237nm)	Min. 400	Min. 400
Absorbance ratio (237nm / 222nm)	1.2 to 1.6	1.2 to 1.6

Areas of application:
PHMB is widely used in oil field chemicals, water treatment chemicals, daily chemicals, textile printing and dyeing, swimming pool disinfection, flower antiseptic treatment, animal husbandry, aquaculture, agriculture, pet antibacterial, soil improvement, environmental disinfection, disinfection products, etc.
In aquaculture, HPMB can rapidly inhibit Gram-negative bacteria, floating Vibrio, Vibrio parahaemolyticus, Vibrio algolyticus and other harmful bacteria in seawater, and has good preventive and therapeutic effects on various diseases caused by bacteria in South American white shrimp and other aquatic products.

Chemical Name:
Poly(iminoimidocarbonyliminoimidocarbonyliminohexamethylene),hydrochloride;
Poly(hexamethylenebiguanide) hydrochloride;
Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl), hydrochloride;
Poly(hexamethylene diguanide) hydrochloride；
Poly[imino(carbonimidoyl)imino(carbonimidoyl)iminohexane-1,6-diyl] hydrochloride (1:?);
Guanidine,N,N”’-1,6-hexanediylbis[N’-cyano-,polymer with 1,6-hexanediamine, hydrochloride;
N,N”’-1,6-Hexanediylbis(N’-cyanoguanidine),hexamethylenediamine polymer, hydrochloride;