PHMB hydrochloride;
PolyHexaMethylene Biguanide, hydrochloride;
CAS Number: 32289-58-0; 27083-27-8;
Polyaminopropyl Biguanide; ポリアミノプロピルビグアニド;

PHMB hydrochloride, a cationic broad-spectrum antimicrobial agent, achieves bactericidal purpose by inhibiting cell membrane activity.

As a cell membrane active antimicrobial agent, PHMB inhibits bacterial activity better than that of fungi.

Antimicrobial mechanism

PHMB is a polymerized cationic compound, which is easily adsorbed by various types of bacteria that are usually negatively charged, thus inhibiting the division function of the bacteria and making the bacteria lose the ability to reproduce.

Related Product

PHMG chloride (PolyHexaMethylene Guanidine, hydrochloride);
CAS No.: 57028-96-3;

Technical Data

	PHMB 20% Solution	PHMB Solid
Appearance	Colorless clear to slightly pale yellow liquid	White to slight yellow hygroscopic powder
Odor	Characteristic	Characteristic
Turbidity [NTU]	Max. 10	—
Solid component [％]	19.0 to 21.0	Min. 95.0
Density at 20℃ [g/ml]	1.039 to 1.050	—
pH-Value at 25℃	4 to 6	4 to 7
Absorbance value (1%, 237nm)	Min. 400	Min. 400
Absorbance ratio (237nm / 222nm)	1.2 to 1.6	1.2 to 1.6

PHMB Features

1. PHMB has the ability to inhibit Gram-positive bacteria, Gram-negative bacteria, fungi (many kinds of ringworm and mold) and yeast.
2. PHMB has rapid inhibitory effect on E. coli, Staphylococcus aureus and Candida albicans.
3. PHMB: LD50＞5000mg/kg, HPMB is skin friendly, human and environment friendly.

Uses

PHMB is widely used in oil field chemicals, water treatment chemicals, daily chemicals, textile printing and dyeing, swimming pool disinfection, flower antiseptic treatment, animal husbandry, aquaculture, agriculture, pet antibacterial, soil improvement, environmental disinfection, disinfection products, etc.
In aquaculture, PHMB can rapidly inhibit Gram-negative bacteria, floating Vibrio, Vibrio parahaemolyticus, Vibrio algolyticus and other harmful bacteria in seawater, and has good preventive and therapeutic effects on various diseases caused by bacteria in South American white shrimp and other aquatic products.

Biocidal Active substances

Quaternary Ammonium (Quats)

PHMB Chemical Formula:
1. CAS# 32289-58-0 (EC# 687-569-4; 608-723-9);
(C8H17N5·ClH)n; Poly(iminoimidocarbonyliminoimidocarbonyliminohexamethylene), hydrochloride;
2. CAS# 27083-27-8 (EC# 608-042-7);
(C10H18N8·C6H16N2)x·xClH;
Guanidine, N,N”’-1,6-hexanediylbis[N’-cyano-, polymer with1,6-hexanediamine, hydrochloride;
3. CAS# 91403-50-8 (EC# 618-745-0);
IUPAC names: Poly(hexamethylenbiguanid)-hydrochlorid

PHMB Chemical Name:
Poly(iminoimidocarbonyliminoimidocarbonyliminohexamethylene),hydrochloride;
Poly(hexamethylenebiguanide) hydrochloride;
Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl), hydrochloride;
Poly(hexamethylene diguanide) hydrochloride；
Poly[imino(carbonimidoyl)imino(carbonimidoyl)iminohexane-1,6-diyl] hydrochloride (1:?);
Guanidine,N,N”’-1,6-hexanediylbis[N’-cyano-,polymer with 1,6-hexanediamine, hydrochloride;
N,N”’-1,6-Hexanediylbis(N’-cyanoguanidine),hexamethylenediamine polymer, hydrochloride;